樊芳芳，女，博士，副教授，2020年6月毕业于厦门大学化学与化工学院，物理化学专业理论与计算化学方向，获得理学博士学位，2020年7月进入浙江科技大学任教。主要从事生物酶催化体系的多尺度理论计算模拟和计算机辅助药物/酶分子设计。

获批项目及资助：

1. 国家自然科学基金-青年项目，磷酸三酯酶降解神经毒剂VX催化机理和调控机制的理论研究，2022.01-2024.12，主持。

2. 厦门大学固体表面物理化学国家重点实验室开放课题，基于QM/MM方法对磷酸三酯酶降解神经毒剂的理论研究,2022.01-2023.12，主持。

3. 浙江科技大学基本科研业务费专项资金项目，基于QM/MM方法对磷酸三酯酶降解神经毒剂的理论研究，2021.01-2022.12，主持。

4. 浙江科技大学“课程思政”示范课程立项项目，2021.01-2023.12，主持。

第一作者及通讯作者论文：

1. Linyu Chen,Fangfang Fan*, Meiyuan Yang, Linquan Wang, Yushuo Bai, Shuai Qiu, Changjiang Lyu, Jun Huang. Atomistic insight into the binding mode and self-regulation mechanism ofIsPETase towards PET substrates with different polymerization degrees.Physical Chemistry Chemical Physics2023, 25(27):18332-18345.

2.Fangfang Fan, Chunyan Liu, Jiaren Cao, Changjiang Lyu, Shuai Qiu, Sheng Hu, Tingting Sun, Jiaqi Mei, Hongpeng Wang, Ye Li, Weirui Zhao, Lehe Mei*, Jun Huang*. Turning thermostability ofAspergillus terreus(R)-selective transaminase At-ATA by synthetic shuffling.Journal of Biotechnology2023, 364:66-74.

3. Zhiyang Zhang, Jianwu Lv, Yu Wang, Hongli Yu, Baolin Guo, Jihang Zhai, Chaojie Wang, Yuan Zhao*,Fangfang Fan*, Wen Luo*. Static Binding and Dynamic Transporting-Based Design of Specific Ring-Chain-Ring Acetylcholinesterase Inhibitor: From Galantamine to Natural Product.Chemistry-A European Journal2023, 29(25):e202203363.

4.Fangfang Fan, Yongchao Zheng^*, Yuzhuang Fu, Yuwei Zhang, He Zheng, Changjiang Lyu, Linyu Chen, Jun Huang*, Zexing Cao*. QM/MM and MM MD simulations on decontamination of the V-type nerve agent VX by phosphotriesterase: toward a comprehensive understanding of steroselectivity and activity.Physical Chemistry Chemical Physics2022, 24(18):10933-10943.

5. Yuzhuang Fu, Yuwei Zhang,Fangfang Fan*, Binju Wang*, Zexing Cao*. Degradation of pesticides diazinon and diazoxon by phosphotriesterase: insight into divergent mechanisms from QM/MM and MD simulations.Physical Chemistry Chemical Physics. 2022, 24(2):687-696.

6.樊芳芳,付玉状,曹泽星*.酶催化过程的量子-经典力学研究进展.科学通报,2021, (10):1131-1143.

7. Jia-Ren Cao^#,Fang-Fang Fan^#, Chang-Jiang Lv^#, Hong-Peng Wang, Ye Li, Sheng Hu, Wei-Rui Zhao, Hai-Bin Chen, Jun Huang*, Le-He Mei*. Improving the Thermostability and Activity of Transaminase FromAspergillus terreusby Charge-Charge Interaction.Frontiers in Chemistry2021, 9:664156.

8. Zhiyang Zhang^#,Fangfang Fan^#, Wen Luo, Yuan Zhao*, Chaojie Wang*, Molecular Dynamics Studies Revealing a Detour-forward Release Mechanism of Tacrine: Implication for the Specific Binding Characteristics in Butyrylcholinesterase (BChE).Frontiers in Chemistry2020, 8

9.Fangfang Fan, Yuan Zhao*, Zexing Cao*, Insight into delivery channel and selectivity of multiple binding sites in bovine serum albumin towards naphthalimide-polyamine derivatives.Physical Chemistry Chemical Physics2019, 21, 7429-7439.

10.Fangfang Fan^#, Yongchao Zheng^#, Yuwei Zhang, He Zheng, Jinyi Zhong*, Zexing Cao*, A Comprehensive Understanding of Enzymatic Degradation of the G-Type Nerve Agent by Phosphotriesterase: Revised Role of Water Molecules and Rate-Limiting Product Release.ACS Catalysis2019, 9, 7038-7051.

11.Fangfang Fan, Nanhao Chen, Yongheng Wang, Ruibo Wu, Zexing Cao*, QM/MM and MM MD Simulations on the Pyrimidine-Specific Nucleoside Hydrolase: A Comprehensive Understanding of Enzymatic Hydrolysis of Uridine.Journal of Physical Chemistry B2018. 122, 1121-1131.

邮箱：fffan@zust.edu.cn